hITGA4/MC-38
CBPG0281
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| I. Background | |
| ITGA4基因编码整合素α4亚基(Integrin subunit alpha 4),这是一种在免疫细胞表面发挥关键作用的黏附分子。它必须与整合素β1或β7亚基结合形成异二聚体,才能发挥功能,这些受体(如VLA-4和α4β7)介导淋巴细胞迁移、归巢至炎症组织和特定器官,并在免疫应答调节中扮演重要角色。在临床上,ITGA4是治疗多发性硬化、炎症性肠病等自身免疫疾病的重要药物靶点,也因其在多种癌症中的异常表达和功能,成为肿瘤诊断、预后评估及预测免疫治疗疗效的潜在生物标志物。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hITGA4 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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